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Biochemistry

Succinate strikes

The high levels of tissue-damaging reactive oxygen species that arise during a stroke or heart attack have been shown to be generated through the accumulation of the metabolic intermediate succinate. See Letter p.431

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Figure 1: Succinate in inflammation and infarct.

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Correspondence to Luke A. J. O'Neill.

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O'Neill, L. Succinate strikes. Nature 515, 350–351 (2014). https://doi.org/10.1038/nature13941

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