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Developmental biology

Polarize to elongate

An analysis of fruit-fly embryos reveals that receptor proteins of the Toll family direct the oriented cell rearrangements required for the elongation of the head-to-tail axis during development. See Article p.523

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Figure 1: Cell rearrangement in the Drosophila melanogaster germband.


  1. Paré, A. C. et al. Nature 515, 523–527 (2014).

    Article  ADS  Google Scholar 

  2. Irvine, K. D. & Wieschaus, E. Development 120, 827–841 (1994).

    CAS  PubMed  Google Scholar 

  3. Walck-Shannon, E. & Hardin, J. Nature Rev. Mol. Cell Biol. 15, 34–48 (2014).

    Article  CAS  Google Scholar 

  4. Vichas, A. & Zallen, J. A. Semin. Cell Dev. Biol. 22, 858–864 (2011).

    Article  CAS  Google Scholar 

  5. Collinet, C. & Lecuit, T. Prog. Mol. Biol. Transl. Sci. 116, 25–47 (2013).

    Article  CAS  Google Scholar 

  6. Zallen, J. A. & Wieschaus, E. Dev. Cell 6, 343–355 (2004).

    Article  CAS  Google Scholar 

  7. Kambris, Z., Hoffmann, J. A., Imler, J. L. & Capovilla, M. Gene Expr. Patterns 2, 311–317 (2002).

    Article  CAS  Google Scholar 

  8. Leulier, F. & Lemaitre, B. Nature Rev. Genet. 9, 165–178 (2008).

    Article  CAS  Google Scholar 

  9. Kolesnikov, T. & Beckendorf, S. K. Dev. Biol. 307, 53–61 (2007).

    Article  CAS  Google Scholar 

  10. Levayer, R., Pelissier-Monier, A. & Lecuit, T. Nature Cell Biol. 13, 529–540 (2011).

    Article  CAS  Google Scholar 

  11. Simões, S. de M. et al. Dev. Cell 19, 377–388 (2010).

    Article  Google Scholar 

  12. Simões, S. de M., Mainieri, A. & Zallen, J. A. J. Cell Biol. 204, 575–589 (2014).

    Article  Google Scholar 

  13. Nishimura, T., Honda, H. & Takeichi, M. Cell 149, 1084–1097 (2012).

    Article  CAS  Google Scholar 

  14. Lienkamp, S. S. et al. Nature Genet. 44, 1382–1387 (2012).

    Article  CAS  Google Scholar 

  15. Affolter, M. & Caussinus, E. Development 135, 2055–2064 (2008).

    Article  CAS  Google Scholar 

  16. Warrington, S. J., Strutt, H. & Strutt, D. Development 140, 1045–1054 (2013).

    Article  CAS  Google Scholar 

  17. da Silva, S. M. & Vincent, J. P. Development 134, 3049–3054 (2007).

    Article  Google Scholar 

  18. Butler, L. C. et al. Nature Cell Biol. 11, 859–864 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Ulrich Tepass.

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Tepass, U. Polarize to elongate. Nature 515, 499–501 (2014).

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