Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Metastasis risk after anti-macrophage therapy

Nature volume 515, pages 46–47 (2014)Cite this article

Subjects

Blocking the activity of macrophages may delay the spread of cancer. But new findings show that these immune cells can rapidly rebound to tumours after therapy withdrawal, accelerating lethal metastasis in mice. See Letter p.130

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Monocyte rebounds after therapy.

References

  1. Wynn, T. A., Chawla, A. & Pollard, J. W. Nature 496, 445–455 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Noy, R. & Pollard, J. W. Immunity 41, 49–61 (2014).

    Article  CAS  Google Scholar 

  3. DeNardo, D. G. et al. Cancer Discov. 1, 54–67 (2011).

    Article  CAS  Google Scholar 

  4. Ries, C. H. et al. Cancer Cell 25, 846–859 (2014).

    Article  CAS  Google Scholar 

  5. Qian, B.-Z. et al. Nature 475, 222–225 (2011).

    Article  CAS  Google Scholar 

  6. De Palma, M. & Lewis, C. E. Cancer Cell 23, 277–286 (2013).

    Article  CAS  Google Scholar 

  7. Bonapace, L. et al. Nature 515, 130–133 (2014).

    Article  ADS  CAS  Google Scholar 

  8. Saji, H. et al. Cancer 92, 1085–1091 (2001).

    Article  CAS  Google Scholar 

  9. Squadrito, M. L. & De Palma, M. Mol. Aspects Med. 32, 123–145 (2011).

    Article  CAS  Google Scholar 

  10. Pienta, K. J. et al. Invest. New Drugs 31, 760–768 (2013).

    Article  CAS  Google Scholar 

  11. Pahler, J. C. et al. Neoplasia 10, 329–339 (2008).

    Article  CAS  Google Scholar 

  12. Swierczak, A. et al. Cancer Immunol. Res. 2, 765–776 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ioanna Keklikoglou and Michele De Palma are at the Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.,

    Ioanna Keklikoglou & Michele De Palma

Authors
  1. Ioanna Keklikoglou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michele De Palma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michele De Palma.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Keklikoglou, I., De Palma, M. Metastasis risk after anti-macrophage therapy. Nature 515, 46–47 (2014). https://doi.org/10.1038/nature13931

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13931

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer