Extended Data Figure 2 : Consumption of a HFD limits hyperinflammatory cytokine production in Pstpip2cmo mutant mice.

From: Dietary modulation of the microbiome affects autoinflammatory disease

Extended Data Figure 2

a, Wild-type and Pstpip2cmo mutant mice were fed a LFD or HFD for 12 weeks. Relative expression of Cxcl1 (wild type n = 8; LFD Pstpip2cmo n =  4; HFD Pstpip2cmo n =  9) and Il6 (wild type n = 11; LFD Pstpip2cmo n =  10; HFD Pstpip2cmo n =  8) in the hind paws was determined by qRT–PCR. The bar graphs depict combined data from two independent experiments. Data are shown as mean ± s.e.m. b, Wild-type and Pstpip2cmo mutant mice were fed a LFD or a HFD for 12 weeks and cytokines levels in the hind paws were determined by ELISA. Combined data are from two independent experiments. Each point represents an individual mouse, and the line represents the mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001; Student’s t-test.