The spliceosome enzyme complex removes intron sequences from RNA transcripts to form messenger RNA. The crystal structure of a lasso-shaped RNA suggests a mechanism for this splicing process. See Article p.193
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Berget, S. M., Moore, C. & Sharp, P. A. Proc. Natl Acad. Sci. USA 74, 3171–3175 (1977).
Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts R. J. Cell 12, 1–8 (1977).
Robart, A. R., Chan, R. T., Peters, J. K., Rajashankar, K. R. & Toor, N. Nature 514, 193–197 (2014).
Podar, M., Chu, V. T., Pyle, A. M. & Perlman, P. S. Nature 391, 915–918 (1998).
Martin, W. & Koonin, E. V. Nature 440, 41–45 (2006).
Lambowitz, A. M. & Zimmerly, S. Cold Spring Harb. Perspect. Biol. 3, a003616 (2011).
Toor, N., Keating, K. S., Taylor, S. D. & Pyle, A. M. Science 320, 77–82 (2008).
Fica, S. M., Mefford, M. A., Piccirilli, J. A. & Staley, J. P. Nature Struct. Mol. Biol. 21, 464–471 (2014).
Pyle, A. M. Crit. Rev. Biochem. Mol. Biol. 45, 215–232 (2010).
Query, C. C., Moore, M. J. & Sharp, P. A. Genes Dev. 8, 587–597 (1994).
Cech, T. R. Cold Spring Harb. Symp. Quant. Biol. 74, 11–16 (2009).
Galej, W. P., Oubridge, C., Newman, A. J. & Nagai, K. Nature 493, 638–643 (2013).
Amunts, A. et al. Science 343, 1485–1489 (2014).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Batey, R. Lariat lessons. Nature 514, 173–174 (2014). https://doi.org/10.1038/nature13754
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature13754