Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Lariat lessons

The spliceosome enzyme complex removes intron sequences from RNA transcripts to form messenger RNA. The crystal structure of a lasso-shaped RNA suggests a mechanism for this splicing process. See Article p.193

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Self-splicing reactions of group II introns.
Figure 2: Cartoon of the domain organization of group II introns.


  1. Berget, S. M., Moore, C. & Sharp, P. A. Proc. Natl Acad. Sci. USA 74, 3171–3175 (1977).

    CAS  Article  ADS  Google Scholar 

  2. Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts R. J. Cell 12, 1–8 (1977).

    CAS  Article  Google Scholar 

  3. Robart, A. R., Chan, R. T., Peters, J. K., Rajashankar, K. R. & Toor, N. Nature 514, 193–197 (2014).

    CAS  Article  ADS  Google Scholar 

  4. Podar, M., Chu, V. T., Pyle, A. M. & Perlman, P. S. Nature 391, 915–918 (1998).

    CAS  Article  ADS  Google Scholar 

  5. Martin, W. & Koonin, E. V. Nature 440, 41–45 (2006).

    CAS  Article  ADS  Google Scholar 

  6. Lambowitz, A. M. & Zimmerly, S. Cold Spring Harb. Perspect. Biol. 3, a003616 (2011).

    Article  Google Scholar 

  7. Toor, N., Keating, K. S., Taylor, S. D. & Pyle, A. M. Science 320, 77–82 (2008).

    CAS  Article  ADS  Google Scholar 

  8. Fica, S. M., Mefford, M. A., Piccirilli, J. A. & Staley, J. P. Nature Struct. Mol. Biol. 21, 464–471 (2014).

    CAS  Article  Google Scholar 

  9. Pyle, A. M. Crit. Rev. Biochem. Mol. Biol. 45, 215–232 (2010).

    CAS  Article  Google Scholar 

  10. Query, C. C., Moore, M. J. & Sharp, P. A. Genes Dev. 8, 587–597 (1994).

    CAS  Article  Google Scholar 

  11. Cech, T. R. Cold Spring Harb. Symp. Quant. Biol. 74, 11–16 (2009).

    CAS  Article  Google Scholar 

  12. Galej, W. P., Oubridge, C., Newman, A. J. & Nagai, K. Nature 493, 638–643 (2013).

    CAS  Article  ADS  Google Scholar 

  13. Amunts, A. et al. Science 343, 1485–1489 (2014).

    CAS  Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Robert T. Batey.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Batey, R. Lariat lessons. Nature 514, 173–174 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing