Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

DNA repair

Making the cut

Analysis of the first step in repairing double-stranded-DNA breaks reveals that the Mre11 enzyme makes a DNA nick at a point separate from the break ends, creating an entry site for further processing by exonuclease enzymes. See Letter p.122

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Resection in the right direction.

References

  1. 1

    Cannavo, E. & Cejka, P. Nature 514, 122–125 (2014).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Mimitou, E. P. & Symington, L. S. Nature 455, 770–774 (2008).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E. & Ira, G. Cell 134, 981–994 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Cannavo, E., Cejka, P. & Kowalczykowski, S. C. Proc. Natl Acad. Sci. USA 110, E1661–E1668 (2013).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Niu, H. et al. Nature 467, 108–111 (2010).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Cejka, P. et al. Nature 467, 112–116 (2010).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Paull, T. T. & Gellert, M. Mol. Cell 1, 969–979 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Lengsfeld, B. M., Rattray, A. J., Bhaskara, V., Ghirlando, R. & Paull, T. T. Mol. Cell 28, 638–651 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Garcia, V., Phelps, S. E. L., Gray, S. & Neale, M. J. Nature 479, 241–244 (2011).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Lammens, K. et al. Cell 145, 54–66 (2011).

    CAS  Article  Google Scholar 

  11. 11

    Lim, H. S., Kim, J. S., Park, Y. B., Gwon, G. H. & Cho, Y. Genes Dev. 25, 1091–1104 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Huertas, P., Cortés-Ledesma, F., Sartori, A. A., Aguilera, A. & Jackson, S. P. Nature 455, 689–692 (2008).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Alani, E., Padmore, R. & Kleckner, N. Cell 61, 419–436 (1990).

    CAS  Article  Google Scholar 

  14. 14

    Wang, H. et al. Mol. Cell 54, 1012–1021 (2014).

    CAS  Article  Google Scholar 

  15. 15

    Makharashvili, N. et al. Mol. Cell 54, 1022–1033 (2014).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Lorraine S. Symington.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Symington, L. Making the cut. Nature 514, 39–40 (2014). https://doi.org/10.1038/nature13751

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing