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Structural biology

Ribosome revelations

Proteins are synthesized in cells by the ribosome apparatus. A report of 16 yeast ribosome structures, each bound by a different inhibitor, broadens our understanding of how drugs affect ribosome activity. See Article p.517

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Figure 1: Binding sites of protein-translation inhibitors in the yeast ribosome.


  1. Garreau de Loubresse, N. et al. Nature 513, 517–522 (2014).

    Article  CAS  ADS  Google Scholar 

  2. Wilson, D. N. Crit. Rev. Biochem. Mol. Biol. 44, 393–433 (2009).

    Article  CAS  Google Scholar 

  3. Wimberley, B. T. Curr. Opin. Invest. Drugs 10, 750–765 (2009).

    Google Scholar 

  4. Perez-Fernandez, D. et al. Nature Commun. 5, 3112; (2014).

    Article  ADS  Google Scholar 

  5. Taguchi, A. et al. ChemMedChem (2014).

  6. Schneider-Poetsch, T. et al. Nature Chem. Biol. 6, 209–217 (2010).

    Article  CAS  Google Scholar 

  7. Schuwirth, B. S. et al. Science 310, 827–834 (2005).

    Article  CAS  ADS  Google Scholar 

  8. Wong, W. et al. eLife 3, e03080 (2014).

    Article  Google Scholar 

  9. Bai, X., Fernandez, I. S., McMullan, G. & Scheres, S. H. eLife 2, e00461 (2013).

    Article  Google Scholar 

Download references

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Correspondence to Nelson B. Olivier.

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Olivier, N. Ribosome revelations. Nature 513, 491–492 (2014).

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