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Immunology

Mammalian watchdog targets bacteria

Nature volume 512, pages 377–378 (2014)Cite this article

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The aryl hydrocarbon receptor elicits protection against toxic environmental molecules. New data show that the receptor also supports the immune system by recognizing bacterially encoded virulence factors. See Article p.387

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Figure 1: AhR senses bacterial virulence factors and regulates host defence.

References

  1. Theis, K. R. et al. Proc. Natl Acad. Sci. USA 110, 19832–19837 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Moura-Alves, P. et al. Nature 512, 387–392 (2014).

    Article  ADS  CAS  Google Scholar 

  3. Denison, M. S. & Nagy, S. R. Annu. Rev. Pharmacol. Toxicol. 43, 309–334 (2003).

    Article  CAS  Google Scholar 

  4. Ohtake, F. et al. Nature 446, 562–566 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Stockinger, B., Di Meglio, P., Gialitakis, M. & Duarte, J. H. Annu. Rev. Immunol. 32, 403–432 (2014).

    Article  CAS  Google Scholar 

  6. Pierson, L. S. III & Pierson, E. A. Appl. Microbiol. Biotechnol. 86, 1659–1670 (2010).

    Article  CAS  Google Scholar 

  7. De Vleesschauwer, D., Cornelis, P. & Hofte, M. Mol. Plant Microbe Interact. 19, 1406–1419 (2006).

    Article  CAS  Google Scholar 

  8. Mavrodi, D. V. et al. Appl. Environ. Microbiol. 76, 866–879 (2010).

    Article  CAS  Google Scholar 

  9. Smith, T. J. Exp. Med. 2, 543–547 (1897).

    Article  CAS  Google Scholar 

  10. Zelante, T. et al. Immunity 39, 372–385 (2013).

    Article  CAS  Google Scholar 

  11. Jin, G. B., Moore, A. J., Head, J. L., Neumiller, J. J. & Lawrence, B. P. Toxicol. Sci. 116, 514–522 (2010).

    Article  CAS  Google Scholar 

  12. Inoue, H. et al. J. Immunol. 188, 4654–4662 (2012).

    Article  CAS  Google Scholar 

  13. Bessede, A. et al. Nature 511, 184–190 (2014).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Parag Kundu and Sven Pettersson are in the Lee Kong Chian School of Medicine and the Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551.,

    Parag Kundu & Sven Pettersson

  2. Singapore and in the Department of Microbiology, S.P. is also at the National Cancer Center, Singapore General Hospital, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.,

    Sven Pettersson

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  1. Parag Kundu
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  2. Sven Pettersson
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Correspondence to Sven Pettersson.

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Kundu, P., Pettersson, S. Mammalian watchdog targets bacteria. Nature 512, 377–378 (2014). https://doi.org/10.1038/nature13741

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