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Biological techniques

Edit the genome to understand it

Nature volume 513, pages 40–41 (2014)Cite this article

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Genome editing followed by sequencing has now been used to engineer and analyse every variation of several stretches of human DNA in living cells, providing insight into the function of each constituent nucleotide molecule. See Letter p.120

You were shaped by both nature and nurture, by your DNA and your environment. How do the differences in your genome, compared with those of other people, affect who you are? In this issue, Findlay et al.1 (page 120) put a combination of human-genome editing2 and in-depth gene sequencing to brilliant use, and bring us one large step closer to a general answer to this monumental question.

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Figure 1: The search for meaning.

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Authors and Affiliations

  1. Fyodor D. Urnov is at Sangamo BioSciences Inc., Richmond, California 94804, USA.,

    Fyodor D. Urnov

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  1. Fyodor D. Urnov
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Correspondence to Fyodor D. Urnov.

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Urnov, F. Edit the genome to understand it. Nature 513, 40–41 (2014). https://doi.org/10.1038/nature13659

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