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Biological techniques

Edit the genome to understand it

Genome editing followed by sequencing has now been used to engineer and analyse every variation of several stretches of human DNA in living cells, providing insight into the function of each constituent nucleotide molecule. See Letter p.120

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Figure 1: The search for meaning.


  1. Findlay, G. M., Boyle, E. A., Hause, R. J., Klein, J. C. & Shendure, J. Nature 513, 120–123 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Carroll, D. Annu. Rev. Biochem. 83, 409–439 (2014).

    Article  CAS  Google Scholar 

  3. Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S. & Gregory, P. D. Nature Rev. Genet. 11, 636–646 (2010).

    Article  CAS  Google Scholar 

  4. Joung, J. K. & Sander, J. D. Nature Rev. Mol. Cell Biol. 14, 49–55 (2013).

    Article  CAS  Google Scholar 

  5. Ran, F. A. et al. Nature Protocols 8, 2281–2308 (2013).

    Article  CAS  Google Scholar 

  6. Urnov, F. D. et al. Nature 435, 646–651 (2005).

    Article  ADS  CAS  Google Scholar 

  7. Goldberg, A. D. et al. Cell 140, 678–691 (2010).

    Article  CAS  Google Scholar 

  8. Doyon, J. B. et al. Nature Cell Biol. 13, 331–337 (2011).

    Article  CAS  Google Scholar 

  9. Sexton, A. et al. Genes Dev. (2014).

  10. Braberg, H. et al. Cell 154, 775–788 (2013).

    Article  CAS  Google Scholar 

  11. Robertson, M. Nature 285, 358–359 (1980).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Fyodor D. Urnov.

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Urnov, F. Edit the genome to understand it. Nature 513, 40–41 (2014).

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