Ageing is accompanied by deterioration in the haematopoietic stem cells that are responsible for regenerating the blood system. Cellular stress in the aged stem cells could be a cause of this decline. See Letter p.198
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Bartek, J., Hodny, Z. Old blood stem cells feel the stress. Nature 512, 140–141 (2014). https://doi.org/10.1038/nature13652
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