Mice deficient in the EDA protein lack normal tooth features. Restoring EDA in embryonic teeth at increasing doses has now been found to recover these dental features in a stepwise pattern that mimics evolution. See Article p.44
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells
Scientific Reports Open Access 07 December 2015
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gould, S. J. Ontogeny and Phylogeny (Belknap, 1985).
Abzhanov, A. Trends Genet. 29, 712–722 (2013).
Harjunmaa, E. et al. Nature 512, 44–48 (2014).
Kielan-Jaworowska, Z., Cifelli, R. L. & Luo, Z.-X. Mammals from the Age of Dinosaurs: Origins, Evolution, and Structure (Columbia Univ. Press, 2004).
Crompton, A. W. Zool. J. Linn. Soc. 50 (Suppl. 1), 65–87 (1971).
Luo, Z.-X., Cifelli, R. L. & Kielan-Jaworowska, Z. Nature 409, 53–57 (2001).
Meng, J. & Wyss, A. R. J. Mamm. Evol. 8, 1–71 (2007).
Gomes-Rodrigues, H. et al. Nature Commun. 4, 2504 (2013).
Charles, C. et al. Proc. Natl Acad. Sci. USA 106, 22364–22368 (2009).
Mikkola, M. J. & Thesleff, I. Cytokine Growth Factor Rev. 14, 211–224 (2003).
Cho, S.-W. et al. Development 138, 1807–1816 (2011).
Luo, Z.-X., Ji, Q. & Yuan, C.-X. Nature 450, 93–97 (2007).
Carroll, S. B., Grenier, J. K. & Weatherbee, S. D. From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design 2nd edn (Blackwell, 2005).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Luo, ZX. Tooth structure re-engineered. Nature 512, 36–37 (2014). https://doi.org/10.1038/nature13651
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature13651
This article is cited by
-
Reply to: Jaw roll and jaw yaw in early mammals
Nature (2020)
-
Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells
Scientific Reports (2015)