Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


One cell at a time


Single-cell DNA sequencing of two breast-cancer types has shown extensive mutational variation in individual tumours, confirming that generation of genetic diversity may be inherent in how tumours evolve. See Article p.155

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Levels of diversity.


  1. Stratton, M. R., Campbell, P. J. & Futreal, P. A. Nature 458, 719–724 (2009).

    Article  CAS  ADS  Google Scholar 

  2. Nature Meth. 11, 1 (2014).

  3. Wang, Y. et al. Nature 512, 155–160 (2014).

    Article  CAS  ADS  Google Scholar 

  4. Navin, N. et al. Nature 472, 90–94 (2011).

    Article  CAS  ADS  Google Scholar 

  5. Schmitt, M. W. et al. Proc. Natl Acad. Sci. USA 109, 14508–14513 (2012).

    Article  CAS  ADS  Google Scholar 

  6. Zong, C., Lu, S., Chapman, A. R. & Xie, X. S. Science 338, 1622–1626 (2012).

    Article  CAS  ADS  Google Scholar 

  7. Shapiro, E., Biezuner, T. & Linnarsson, S. Nature Rev. Genet. 14, 618–630 (2013).

    Article  CAS  Google Scholar 

  8. Xu, X. et al. Cell 148, 886–895 (2012).

    Article  CAS  Google Scholar 

  9. Hou, Y. et al. Cell 148, 873–885 (2012).

    Article  CAS  Google Scholar 

  10. Tougeron, D. et al. Ann. Oncol. 24, 1267–1273 (2013).

    Article  CAS  Google Scholar 

  11. Loeb, L. A., Springgate, C. F. & Battula, N. Cancer Res. 34, 2311–2321 (1974).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Edward J. Fox or Lawrence A. Loeb.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fox, E., Loeb, L. One cell at a time. Nature 512, 143–144 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer