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Epigenetics

Cellular memory erased in human embryos

Nature volume 511, pages 540–541 (2014)Cite this article

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Two analyses of human eggs, sperm and early-stage embryos reveal a pronounced loss of DNA methylation — a molecular modification that affects gene transcription — after fertilization. See Letters p.606 & p.611

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Figure 1: Tracking the state of DNA methylation.

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Authors and Affiliations

  1. Wolf Reik and Gavin Kelsey are in the Epigenetics Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK, and at the Centre for Trophoblast Research, University of Cambridge.,

    Wolf Reik & Gavin Kelsey

  2. W.R. is also at the Wellcome Trust Sanger Institute, Cambridge.,

    Wolf Reik

Authors
  1. Wolf Reik
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  2. Gavin Kelsey
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Reik, W., Kelsey, G. Cellular memory erased in human embryos. Nature 511, 540–541 (2014). https://doi.org/10.1038/nature13648

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