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HIV

Early treatment may not be early enough

Giving monkeys antiretroviral therapy from just three days after exposure to simian immunodeficiency virus does not prevent a subsequent rebound of viral replication, suggesting that viral reservoirs are established early. See Letter p.74

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Figure 1: SIV eradication strategies.

References

  1. Finzi, D. et al. Science 278, 1295–1300 (1997).

    ADS  CAS  Article  Google Scholar 

  2. Chun, T.-W. et al. Proc. Natl Acad. Sci. USA 94, 13193–13197 (1997).

    ADS  CAS  Article  Google Scholar 

  3. Finzi, D. et al. Nat. Med. 5, 512–517 (1999).

    CAS  Article  Google Scholar 

  4. Siliciano, J. D. et al. Nature Med. 9, 727–728 (2003).

    CAS  Article  Google Scholar 

  5. Richman, D. D. et al. Science 323, 1304–1307 (2009).

    ADS  CAS  Article  Google Scholar 

  6. Whitney, J. B. et al. Nature 512, 74–77 (2014).

    ADS  CAS  Article  Google Scholar 

  7. Chun, T.-W. et al. Proc. Natl Acad. Sci. USA 95, 8869–8873 (1998).

    ADS  CAS  Article  Google Scholar 

  8. Chun, T.-W. et al. J. Infect. Dis. 195, 1762–1764 (2007).

    CAS  Article  Google Scholar 

  9. Hocqueloux, L. et al. J. Antimicrob. Chemother. 68, 1169–1178 (2013).

    CAS  Article  Google Scholar 

  10. Ananworanich, J. et al. PLoS ONE 7, e33948 (2012).

    ADS  CAS  Article  Google Scholar 

  11. Salgado, M. et al. Retrovirology 8, 97 (2011).

    CAS  Article  Google Scholar 

  12. Sáez-Cirión, A. et al. PLoS Pathogens 9, e1003211 (2013).

    Article  Google Scholar 

  13. Persaud, D. et al. N. Engl. J. Med. 369, 1828–1835 (2013).

    CAS  Article  Google Scholar 

  14. Ledford, H. Nature http://dx.doi.org/10.1038/nature.2014.15535 (2014).

  15. Hill, A. L., Rosenbloom, D. I. S., Fu, F., Nowak, M. A. & Siliciano, R. F. . Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1406663111 (2014)

  16. Hansen, S. G. et al. Nature 502, 100–104 (2013).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Robert F. Siliciano.

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Deng, K., Siliciano, R. Early treatment may not be early enough. Nature 512, 35–36 (2014). https://doi.org/10.1038/nature13647

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