Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Corralling a protein-degradation regulator

The crystal structure of the COP9 signalosome, a large protein complex that regulates intracellular protein degradation, reveals how the complex achieves exquisite specificity for its substrates. See Article p.161

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Structure of the COP9 signalosome (CSN).


  1. 1

    Wei, N., Chamovitz, D. A. & Deng, X.-W. Cell 78, 117–124 (1994).

    CAS  Article  Google Scholar 

  2. 2

    Lingaraju, G. M. et al. Nature 512, 161–165 (2014).

    CAS  Article  ADS  Google Scholar 

  3. 3

    Lyapina, S. et al. Science 292, 1382–1385 (2001).

    CAS  Article  ADS  Google Scholar 

  4. 4

    Cope, G. A. et al. Science 298, 608–611 (2002).

    CAS  Article  ADS  Google Scholar 

  5. 5

    Fischer, E. S. et al. Cell 147, 1024–1039 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Emberley, E. D., Mosadeghi, R. & Deshaies, R. J. J. Biol. Chem. 287, 29679–29689 (2012).

    CAS  Article  Google Scholar 

  7. 7

    Enchev, R. I. et al. Cell Rep. 2, 616–627 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Ambroggio, X. I., Rees, D. C. & Deshaies, R. J. PLoS Biol. 2, e2 (2004).

    Article  Google Scholar 

  9. 9

    Suh, G. S. B. et al. Neuron 33, 35–46 (2002).

    CAS  Article  Google Scholar 

  10. 10

    Sato, Y. et al. Nature 455, 358–362 (2008).

    CAS  Article  ADS  Google Scholar 

  11. 11

    Pathare, G. R. et al. Proc. Natl Acad. Sci. USA 111, 2984–2989 (2014).

    CAS  Article  ADS  Google Scholar 

  12. 12

    Worden, E. J., Padovani, C. & Martin, A. Nature Struct. Mol. Biol. 21, 220–227 (2014).

    CAS  Article  Google Scholar 

  13. 13

    Śledź, P. et al. Proc. Natl Acad. Sci. USA 110, 7264–7269 (2013).

    Article  ADS  Google Scholar 

  14. 14

    Matyskiela, M. E., Lander, G. C. & Martin, A. Nature Struct. Mol. Biol. 20, 781–788 (2013).

    CAS  Article  Google Scholar 

  15. 15

    Echalier, A. et al. Proc. Natl Acad. Sci. USA 110, 1273–1278 (2013).

    CAS  Article  ADS  Google Scholar 

  16. 16

    Adler, A. S. et al. Cancer Res. 68, 506–515 (2008).

    CAS  Article  Google Scholar 

  17. 17

    Lee, Y.-H. et al. Oncogene 30, 4175–4184 (2011).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Raymond J. Deshaies.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Deshaies, R. Corralling a protein-degradation regulator. Nature 512, 145–146 (2014).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing