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Structural biology

Corralling a protein-degradation regulator

The crystal structure of the COP9 signalosome, a large protein complex that regulates intracellular protein degradation, reveals how the complex achieves exquisite specificity for its substrates. See Article p.161

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Figure 1: Structure of the COP9 signalosome (CSN).

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Correspondence to Raymond J. Deshaies.

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Deshaies, R. Corralling a protein-degradation regulator. Nature 512, 145–146 (2014). https://doi.org/10.1038/nature13644

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