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Neurobiology

Keeping a lid on it

The protein Npas4 dampens activated excitatory brain circuits by recruiting inhibitory signals to excitatory neurons. It emerges that this protein has the opposite role in some inhibitory neurons, promoting their activity.

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Figure 1: Balancing excitation levels.

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Correspondence to Gina Turrigiano.

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Turrigiano, G. Keeping a lid on it. Nature 511, 297–298 (2014). https://doi.org/10.1038/nature13641

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