Extended Data Figure 6 : Rescuing cusps in Eda null teeth by inhibiting SHH.

From: Replaying evolutionary transitions from the dental fossil record

Extended Data Figure 6

Eda null teeth cultured with SHH antagonist show variable morphologies with tightly packed cusps (arrowheads). In addition, in roughly half of the cases (n = 4 of 11 teeth) portions of the first molar appear to form from the fusion with the developing second molar (two bottom rows). Scale bar, 500 µm.