Extended Data Figure 5 : Simulating reduction of inhibition in Eda null teeth.

From: Replaying evolutionary transitions from the dental fossil record

Extended Data Figure 5

Reducing activator inhibition by inhibitor (Inh) or diffusion of inhibitor (Di) results in formation of multiple cusps in simulated Eda null molar. The effects are variable depending on the parameter values, and the lability of the system appears to be corroborated in the in vitro experiments.