Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene regulation

Fine-tuned amplification in cells

The transcription factor Myc has been posited to cause a cell-wide increase in gene expression. But two studies show that Myc, when modulated by other transcription factors, can amplify select targets. See Letters p.483 and p.488

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Models of Myc function.


  1. 1

    Dang, C. V. Cell 149, 22–35 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Sabò, A. et al. Nature 511, 488–492 (2014).

    ADS  Article  Google Scholar 

  3. 3

    Walz, S. et al. Nature 511, 483–487 (2014).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Lovén, J. et al. Cell 151, 476–482 (2012).

    Article  Google Scholar 

  5. 5

    Lin, C. Y. et al. Cell 151, 56–67 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Nie, Z. et al. Cell 151, 68–79 (2012).

    CAS  Article  Google Scholar 

  7. 7

    Cunningham, J. T., Moreno, M. V., Lodi, A., Ronen, S. M. & Ruggero, D. Cell 157, 1088–1103 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Kim, J. et al. Cell 143, 313–324 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. 9

    Elkon, R. et al. Nucleic Acids Res. 32, 4955–4961 (2004).

    CAS  Article  Google Scholar 

  10. 10

    Li, G. W., Burkhardt, D., Gross, C. & Weissman, J. S. Cell 157, 624–635 (2014).

    CAS  Article  Google Scholar 

  11. 11

    Soufi, A., Donahue, G. & Zaret, K. S. Cell 151, 994–1004 (2012).

    CAS  Article  Google Scholar 

  12. 12

    Hart, L. S. et al. J. Clin. Invest. 122, 4621–4634 (2012).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Chi V. Dang.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dang, C. Fine-tuned amplification in cells. Nature 511, 417–418 (2014).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing