News & Views | Published:

Gene regulation

Fine-tuned amplification in cells

Nature volume 511, pages 417418 (24 July 2014) | Download Citation

The transcription factor Myc has been posited to cause a cell-wide increase in gene expression. But two studies show that Myc, when modulated by other transcription factors, can amplify select targets. See Letters p.483 and p.488

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Cell 149, 22–35 (2012).

  2. 2.

    et al. Nature 511, 488–492 (2014).

  3. 3.

    et al. Nature 511, 483–487 (2014).

  4. 4.

    et al. Cell 151, 476–482 (2012).

  5. 5.

    et al. Cell 151, 56–67 (2012).

  6. 6.

    et al. Cell 151, 68–79 (2012).

  7. 7.

    , , , & Cell 157, 1088–1103 (2014).

  8. 8.

    et al. Cell 143, 313–324 (2010).

  9. 9.

    et al. Nucleic Acids Res. 32, 4955–4961 (2004).

  10. 10.

    , , & Cell 157, 624–635 (2014).

  11. 11.

    , & Cell 151, 994–1004 (2012).

  12. 12.

    et al. J. Clin. Invest. 122, 4621–4634 (2012).

Download references

Author information

Affiliations

  1. Chi V. Dang is at the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

    • Chi V. Dang

Authors

  1. Search for Chi V. Dang in:

Corresponding author

Correspondence to Chi V. Dang.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nature13518

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing