Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HIV

The mixed blessing of interferon

A study in monkeys finds that treatment with the protein interferon protects against simian immunodeficiency virus, but that prolonged interferon administration exacerbates the chronic stage of the infection. See Letter p.601

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interferon in acute and chronic infection.

References

  1. Longo, D. L. et al. Ann. NY Acad. Sci. 437, 421–430 (1984).

    Article  CAS  ADS  Google Scholar 

  2. Sandler, G. N. et al. Nature 511, 601–605 (2014).

    Article  CAS  ADS  Google Scholar 

  3. Schoggins, J. W. Curr. Opin. Virol. 6C, 40–46 (2014).

    Article  Google Scholar 

  4. Harris, R. S., Hultquist, J. F. & Evans, D. T. J. Biol. Chem. 287, 40875–40883 (2012).

    Article  CAS  Google Scholar 

  5. Asmuth, D. M. et al. J. Infect. Dis. 201, 1686–1696 (2010).

    Article  CAS  Google Scholar 

  6. Torriani, F. J. et al. N. Engl. J. Med. 351, 438–450 (2004).

    Article  CAS  Google Scholar 

  7. Borden, E. C. & Murphy, F. A. J. Immunol. 106, 134–142 (1971).

    CAS  PubMed  Google Scholar 

  8. Rotger, M. et al. PLoS Pathog. 6, e1000781 (2010).

    Article  Google Scholar 

  9. Bosinger, S. E. et al. J. Clin. Invest. 119, 3556–3572 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Fenton-May, A. E. et al. Retrovirology 10, 146 (2013).

    Article  Google Scholar 

  11. Ivashkiv, L. B. & Donlin, L. T. Nature Rev. Immunol. 14, 36–49 (2014).

    Article  CAS  Google Scholar 

  12. Medzhitov, R., Schneider, D. S. & Soares, M. P. Science 335, 936–941 (2012).

    Article  CAS  ADS  Google Scholar 

  13. Rotger, M. et al. J. Clin. Invest. 121, 2391–2400 (2011).

    Article  CAS  Google Scholar 

  14. Rausell, A., McLaren, P. J. & Telenti, A. F1000Prime Rep. 5, 29 (2013).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amalio Telenti.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Telenti, A. The mixed blessing of interferon. Nature 511, 537–538 (2014). https://doi.org/10.1038/nature13517

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13517

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing