Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

The quest for the perfect reprogrammed cell

There are two methods for reprogramming mature cells to pluripotent stem cells, which can give rise to all cells of the body. The first direct comparison of the methods reveals that both can cause subtle molecular defects. See Article p.177

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparing techniques for generating stem cells.


  1. Tachibana, M. et al. Cell 153, 1228–1238 (2013).

    Article  CAS  Google Scholar 

  2. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  3. Ma, H. et al. Nature 511, 177–183 (2014).

    Article  ADS  CAS  Google Scholar 

  4. Dimos, J. T. et al. Science 321, 1218–1221 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Kim, K. et al. Nature 467, 285–290 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Yamada, M. et al. Nature (2014).

  7. Thomson, J. A. et al. Science 282, 1145–1147 (1998).

    Article  ADS  CAS  Google Scholar 

  8. Gore, A. et al. Nature 471, 63–67 (2011).

    Article  ADS  CAS  Google Scholar 

  9. Bock, C. et al. Cell 144, 439–452 (2011).

    Article  CAS  Google Scholar 

  10. Carey, B. W. et al. Cell Stem Cell 9, 588–598 (2011).

    Article  CAS  Google Scholar 

  11. Gafni, O. et al. Nature 504, 282–286 (2013).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jacob H. Hanna.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Krupalnik, V., Hanna, J. The quest for the perfect reprogrammed cell. Nature 511, 160–162 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing