There are two methods for reprogramming mature cells to pluripotent stem cells, which can give rise to all cells of the body. The first direct comparison of the methods reveals that both can cause subtle molecular defects. See Article p.177
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Krupalnik, V., Hanna, J. The quest for the perfect reprogrammed cell. Nature 511, 160–162 (2014). https://doi.org/10.1038/nature13515