Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Lipopolysaccharide rolls out the barrel

Two crystal structures of the LptD–LptE protein complex reveal how the cell-wall component lipopolysaccharide is delivered and inserted into the external leaflet of the bacterial outer membrane. See Article p.52 & Letter p.108

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structure of the LptD–LptE protein complex.


  1. Dong, H. et al. Nature 511, 52–56 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Qiao, S., Luo, Q., Zhao, Y., Zhang, X.-C. & Huang, Y. Nature 511, 108–111 (2014).

    Article  ADS  CAS  Google Scholar 

  3. Raetz, C. R., Reynolds, C. M., Trent, M. S. & Bishop, R. E. Annu. Rev. Biochem. 76, 295–329 (2007).

    Article  CAS  Google Scholar 

  4. Whitfield, C. & Trent, M. S. Annu. Rev. Biochem. 83, 99–128 (2014).

    Article  CAS  Google Scholar 

  5. Freinkman, E., Okuda, S., Ruiz, N. & Kahne, D. Biochemistry 19, 4800–4806 (2012).

    Article  Google Scholar 

  6. Khan, M. A. & Bishop, R. E. Biochemistry 48, 9745–9756 (2009).

    Article  CAS  Google Scholar 

  7. Cuesta-Seijo, J. A. et al. Structure 18, 1210–1219 (2010).

    Article  CAS  Google Scholar 

  8. Hearn, E. M., Patel, D. R., Lepore, B. W., Indic, M. & van den Berg, B. Nature 458, 367–370 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Lepore, B. W. et al. Proc. Natl Acad. Sci. USA 108, 10121–10126 (2011).

    Article  ADS  CAS  Google Scholar 

  10. Okuda, S., Freinkman, E. & Kahne, D. Science 338, 1214–1217 (2012).

    Article  ADS  CAS  Google Scholar 

  11. Srinivas, N. et al. Science 327, 1010–1013 (2010).

    Article  ADS  CAS  Google Scholar 

  12. Werneburg, M. et al. ChemBioChem 13, 1767–1775 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Russell E. Bishop.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bishop, R. Lipopolysaccharide rolls out the barrel. Nature 511, 37–38 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research