Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Sugar-coated cell signalling

Nature volume 511, pages 298–299 (2014)Cite this article

Subjects

Cell membranes are covered with sugar-conjugated proteins. New findings suggest that the physical properties of this coating, which is more pronounced in cancer cells, regulate cell survival during tumour spread. See Article p.319

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Clustering for survival.

References

  1. Horm, T. M. & Schroeder, J. A. Cell Adhes. Migrat. 7, 187–198 (2013).

    Article  Google Scholar 

  2. Hakomori, S. Cancer Res. 56, 5309–5318 (1996).

    CAS  PubMed  Google Scholar 

  3. Hollingsworth, M. A. & Swanson, B. J. Nature Rev. Cancer 4, 45–60 (2004).

    Article  CAS  Google Scholar 

  4. Paszek, M. J. et al. Nature 511, 319–325 (2014).

    Article  CAS  ADS  Google Scholar 

  5. Hynes, R. O. & Naba, A. Cold Spring Harb. Perspect. Biol. 4, a004903 (2012).

    Article  Google Scholar 

  6. Hood, J. D. & Cheresh, D. A. Nature Rev. Cancer 2, 91–100 (2002).

    Article  Google Scholar 

  7. Campbell, I. D. & Humphries, M. J. Cold Spring Harb. Perspect. Biol. 3, a004994 (2011).

    Article  Google Scholar 

  8. Paszek, M. J., Boettiger, D., Weaver, V. M. & Hammer, D. A. PLoS Comput. Biol. 5, e1000604 (2009).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Andrew J. Ewald is in the Departments of Cell Biology and Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21218, USA.,

    Andrew J. Ewald

  2. Mikala Egeblad is in the Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.,

    Mikala Egeblad

Authors
  1. Andrew J. Ewald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mikala Egeblad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mikala Egeblad.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ewald, A., Egeblad, M. Sugar-coated cell signalling. Nature 511, 298–299 (2014). https://doi.org/10.1038/nature13506

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13506

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer