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Natural-born killers unleashed

The finding that phosphoinositide-3-OH kinase δ restrains the antitumour immune response by promoting the action of suppressive immune cells may broaden the applicability of drugs targeting this enzyme to multiple cancers. See Letter p.407

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Figure 1: Inhibition of PI(3)Kδ releases immune suppression.


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Correspondence to Emilio Hirsch or Francesco Novelli.

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Hirsch, E., Novelli, F. Natural-born killers unleashed. Nature 510, 342–343 (2014).

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