Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Wobble puts RNA on target

Enzymes that attach amino acids to transfer RNAs during protein synthesis must recognize both substrates specifically. Crystal structures reveal a mechanism that explains the RNA specificity for one such system. See Article p.507

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Conformational effects of a single base pair in a transfer RNA.


  1. 1

    Naganuma, M. et al. Nature 510, 507–511 (2014).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Hou, Y.-M. & Schimmel, P. Nature 333, 140–145 (1988).

    ADS  CAS  Article  Google Scholar 

  3. 3

    McClain, W. H. & Foss, K. Science 240, 793–796 (1988).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Giegé, R., Sissler, M. & Florentz, C. Nucleic Acids Res. 26, 5017–5035 (1998).

    Article  Google Scholar 

  5. 5

    Beuning, P. J. & Musier-Forsyth, K. Biopolymers 52, 1–28 (1999).

    CAS  Article  Google Scholar 

  6. 6

    Imura, N., Weiss, G. B. & Chambers, R. W. Nature 222, 1147–1148 (1969).

    ADS  CAS  Article  Google Scholar 

  7. 7

    de Duve, C. Nature 333, 117–118 (1988).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Park, S. J., Hou, Y.-M. & Schimmel, P. Biochemistry 28, 2740–2746 (1989).

    CAS  Article  Google Scholar 

  9. 9

    Musier-Forsyth, K. et al. Science 253, 784–786 (1991).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Musier-Forsyth, K. & Schimmel, P. Nature 357, 513–515 (1992).

    ADS  CAS  Article  Google Scholar 

  11. 11

    McClain, W. H., Chen, Y.-M., Foss, K. & Schneider, J. Science 242, 1681–1684 (1988).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Gabriel, K., Schneider, J. & McClain, W. H. Science 271, 195–197 (1996).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Perona, J. J. & Hadd, A. Biochemistry 51, 8705–8729 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Beebe, K., Mock, M., Merriman, E. & Schimmel, P. Nature 451, 90–93 (2008).

    ADS  CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Karin Musier-Forsyth.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vargas-Rodriguez, O., Musier-Forsyth, K. Wobble puts RNA on target. Nature 510, 480–481 (2014).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing