Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Balancing act

The enzyme parkin is known to promote disposal of organelles called mitochondria that have suffered damage. The identification of an enzyme that opposes parkin demonstrates how a delicate balance is maintained in the cell. See Article p.370

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Maintaining balance in mitophagy.


  1. Bingol, B. et al. Nature 510, 370–375 (2014).

    Article  CAS  ADS  Google Scholar 

  2. Narendra, D., Walker, J. E. & Youle, R. Cold Spring Harb. Perspect. Biol. (2012).

  3. Trempe, J.-F. et al. Science 340, 1451–1455 (2013).

    Article  CAS  ADS  Google Scholar 

  4. Shiba-Fukushima, K. et al. Sci. Rep. 2, 1002 (2012).

    Article  Google Scholar 

  5. Kondapalli, C. et al. Open Biol. 2, 120080 (2012).

    Article  Google Scholar 

  6. Chan, N. C. et al. Hum. Mol. Genet. 20, 1726–1737 (2011).

    Article  CAS  Google Scholar 

  7. Sarraf, S. A. et al. Nature 496, 372–376 (2013).

    Article  CAS  ADS  Google Scholar 

  8. Exner, N., Lutz, A. K., Haass, C. & Winklhofer, K. F. EMBO J. 31, 3038–3062 (2012).

    Article  CAS  Google Scholar 

  9. Greene, J. C. et al. Proc. Natl Acad. Sci. USA 100, 4078–4083 (2003).

    Article  CAS  ADS  Google Scholar 

  10. Sang, T.-K. et al. J. Neurosci. 27, 981–992 (2007).

    Article  CAS  Google Scholar 

  11. Lee, B.-H. et al. Nature 467, 179–184 (2010).

    Article  CAS  ADS  Google Scholar 

  12. Cornelissen, T. et al. Hum. Mol. Genet. (2014).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ordureau, A., Harper, J. Balancing act. Nature 510, 347–348 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing