Extended Data Figure 10 : Neuronal growth factors regulate HSC response to physiological demand.

From: The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Extended Data Figure 10

The neurotrophic factors GDNF, NRTN and ARTN are produced by cells in the HSC microenvironment and act directly on HSCs by activation of RET. Highlighted area: RET stimulation results in p38/MAP kinase and CREB activation leading to Bcl2 and Bcl2l1 expression. RET signals provide HSCs with survival signals that preserve HSC stemness.