An enzyme previously implicated in gene regulation has now been found to have a role in cancer progression, potentiating an intracellular signalling pathway that is driven by a mutated K-Ras protein. See Letter p.283
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References
Pylayeva-Gupta, Y., Grabocka, E. & Bar-Sagi, D. Nature Rev. Cancer 11, 761–774 (2011).
Mazur, P. K. et al. Nature 510, 283–287 (2014).
Hamamoto, R. et al. Nature Cell Biol. 6, 731–740 (2004).
Cuevas, B. D., Abell, A. N. & Johnson, G. L. Oncogene 26, 3159–3171 (2007).
Dhillon, A. S., Hagan, S., Rath, O. & Kolch, W. Oncogene 26, 3279–3290 (2007).
Andreu-Pérez, P. et al. Sci. Signal. 4, ra58 (2011).
Russell, M., Lange-Carter, C. A. & Johnson, G. L. J. Biol. Chem. 270, 11757–11760 (1995).
Karreth, F. A., Frese, K. K., DeNicola, G. M., Baccarini, M. & Tuveson, D. A. Cancer Discov. 1, 128–136 (2011).
Blasco, R. B. et al. Cancer Cell 19, 652–663 (2011).
Cronan, M. R. et al. Oncogene 31, 3889–3900 (2012).
Feldser, D. M. et al. Nature 468, 572–575 (2010).
McCarthy, S. A., Samuels, M. L., Pritchard, C. A., Abraham, J. A. & McMahon, M. Genes Dev. 9, 1953–1964 (1995).
Schulze, A., Lehmann, K., Jefferies, H. B. J., McMahon, M. & Downward, J. Genes Dev. 15, 981–994 (2001).
Sparmann, A. & Bar-Sagi, D. Cancer Cell 6, 447–458 (2004).
Ancrile, B., Lim, K.-H. & Counter, C. M. Genes Dev. 21, 1714–1719 (2007).
Zhao, Q. & Lee, F. S. J. Biol. Chem. 274, 8355–8358 (1999).
Schramek, D. et al. Nature Genet. 43, 212–219 (2011).
Guo, Z. et al. Mol. Cell. Biol. 22, 5761–5768 (2002).
Ferguson, A. D. et al. Structure 19, 1262–1273 (2011).
Ahmad, S., Hughes, M. A., Johnson, G. L. & Scott, J. E. J. Biomol. Screening 18, 388–399 (2013).
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Deuker, M., McMahon, M. Enzyme meets a surprise target. Nature 510, 225–226 (2014). https://doi.org/10.1038/nature13343
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DOI: https://doi.org/10.1038/nature13343