Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Darwinian tumour suppression

Nature volume 509, pages 435–436 (2014)Cite this article

Subjects

Competition for access to a survival factor has been found to explain why incoming cells from the bone marrow replace resident cells in the thymus. Reducing this competition can cause tumours to form. See Article p.465

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cellular competition prevents tumour formation.

References

  1. Martins, V. C. et al. Nature 509, 465–470 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Frey, J. R., Ernst, B., Surh, C. D. & Sprent, J. J. Exp. Med. 175, 1067–1071 (1992).

    Article  CAS  Google Scholar 

  3. Moreno, E., Basler, K. & Morata, G. Nature 416, 755–759 (2002).

    Article  ADS  CAS  Google Scholar 

  4. Raff, M. C. Nature 356, 397–400 (1992).

    Article  ADS  CAS  Google Scholar 

  5. Jiang, Q. et al. Mol. Cell. Biol. 24, 6501–6513 (2004).

    Article  CAS  Google Scholar 

  6. Martins, V. C. et al. J. Exp. Med. 209, 1409–1417 (2012).

    Article  CAS  Google Scholar 

  7. Rhiner, C. et al. Dev. Cell 18, 985–998 (2010).

    Article  CAS  Google Scholar 

  8. Merino, M. M., Rhiner, C., Portela, M. & Moreno, E. Curr. Biol. 23, 1300–1309 (2013).

    Article  CAS  Google Scholar 

  9. Patel, P. H. & Edgar, B. A. Semin. Cell Dev. Biol. http://dx.doi.org/10.1016/j.semcdb.2014.03.012 (2014).

  10. Vincent, J.-P., Fletcher, A. G. & Baena-Lopez, L. A. Nature Rev. Mol. Cell Biol. 14, 581–591 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eduardo Moreno is at the Institute of Cell Biology, IZB, University of Bern, Bern CH-3012, Switzerland.,

    Eduardo Moreno

Authors
  1. Eduardo Moreno
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eduardo Moreno.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Moreno, E. Darwinian tumour suppression. Nature 509, 435–436 (2014). https://doi.org/10.1038/nature13337

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13337

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer