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Structural biology

Action at a distance in a light receptor

A tour de force of X-ray scattering has yielded structures of a phytochrome photoreceptor in its dark and illuminated states, showing how localized protein refolding magnifies a light signal to form a cellular message. See Letter p.245

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Figure 1: Signal magnification in phytochrome light sensors.


  1. Takala, H. et al. Nature 509, 245–248 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Quail, P. H. Nature Rev. Mol. Cell Biol. 3, 85–93 (2002).

    Article  CAS  Google Scholar 

  3. Mandalari, C., Losi, A. & Gärtner, W. Photochem. Photobiol. Sci. 12, 1144–1157 (2013).

    Article  CAS  Google Scholar 

  4. Möglich, A. & Moffat, K. J. Mol. Biol. 373, 112–126 (2007).

    Article  Google Scholar 

  5. Anders, K., Daminelli-Widany, G., Mroginski, M. A., von Stetten, D. & Essen, L.-O. J. Biol. Chem. 288, 35714–35725 (2013).

    Article  CAS  Google Scholar 

  6. Yang, X., Kuk, J. & Moffat, K. Proc. Natl Acad. Sci. USA 105, 14715–14720 (2008).

    Article  ADS  CAS  Google Scholar 

  7. Essen, L.-O., Mailliet, J. & Hughes, J. Proc. Natl Acad. Sci. USA 105, 14709–14714 (2008).

    Article  ADS  CAS  Google Scholar 

  8. Yang, X., Ren, Z., Kuk, J. & Moffat, K. Nature 479, 428–432 (2011).

    Article  ADS  CAS  Google Scholar 

  9. Wagner, J. R., Brunzelle, J. S., Forest, K. T. & Vierstra, R. D. Nature 438, 325–331 (2005).

    Article  ADS  CAS  Google Scholar 

  10. West, A. H. & Stock, A. M. Trends Biochem. Sci. 26, 369–376 (2001).

    Article  CAS  Google Scholar 

  11. Giraud, E. et al. J. Biol. Chem. 280, 32389–32397 (2005).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Anna W. Baker or Katrina T. Forest.

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Baker, A., Forest, K. Action at a distance in a light receptor. Nature 509, 174–175 (2014).

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