Extended Data Figure 7 : SOX2 lineage ablation in pre-existing skin tumours leads to their regression.

From: SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

Extended Data Figure 7

a, Genetic strategy used to perform lineage ablation of SOX2-expressing cells in pre-existing tumours. b, Experimental design. c, Macroscopic pictures of skin papillomas before and after SOX2+ cells lineage ablation. Tamoxifen (TAM) administration to SOX2CreER:Rosa-DTA mice presenting with skin tumours leads to their regression. d, e, Co-immunostaining for K14 (green) and SOX2 protein (red) in papilloma (d) and in carcinoma (e) arising from control (Ctrl) (left) and SOX2CreER:Rosa-DTA (SOX2–DTA) (right) mice. These data show efficient ablation of SOX2-expressing cells. Scale bars, 50 μm.