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Synthetic biology

Biocircuits in synchrony

Cellular biocircuit design has taken a major step forward. The circuit reuses the cell's own protein-degradation system to synchronize the expression of two synthetic modules throughout an entire bacterial population. See Letter p.387

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Figure 1: Climbing up complexity in synthetic biology.


  1. Purnick, P. E. & Weiss, R. Nature Rev. Mol. Cell. Biol. 10, 410–422 (2009).

    Article  CAS  Google Scholar 

  2. Prindle, A. et al. Nature 508, 387–391 (2014).

    Article  ADS  CAS  Google Scholar 

  3. Oklobdzija, V. G. et al. Digital System Clocking: High-Performance and Low-Power Aspects (Wiley, 2003).

    Book  Google Scholar 

  4. Danino, T., Mondragón-Palomino, O., Tsimring, L. & Hasty, J. Nature 463, 326–330 (2010).

    Article  ADS  CAS  Google Scholar 

  5. Stricker, J. et al. Nature 456, 516–519 (2008).

    Article  ADS  CAS  Google Scholar 

  6. Cookson, N. A. et al. Mol. Syst. Biol. 7, 561 (2011).

    Article  Google Scholar 

  7. Kwok, R. Nature 463, 288–290 (2010).

    Article  CAS  Google Scholar 

  8. Tamsir, A., Tabor, J. J. & Voigt, C. A. Nature 469, 212–215 (2011).

    Article  ADS  CAS  Google Scholar 

  9. Regot, S. et al. Nature 469, 207–211 (2011).

    Article  ADS  CAS  Google Scholar 

  10. Solé, R. V. & Macía, J. Nat. Comput. 12, 485–497 (2013).

    Article  MathSciNet  Google Scholar 

Download references

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Correspondence to Ricard Solé or Javier Macía.

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Solé, R., Macía, J. Biocircuits in synchrony. Nature 508, 326–327 (2014).

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