Figure 1: Cellular and bacterial metabolites influence mitochondrial behaviour. | Nature

Figure 1: Cellular and bacterial metabolites influence mitochondrial behaviour.

From: The stressful influence of microbes

Figure 1

When cellular mitochondria sense stressful changes in their environment, they activate a protective program known as the mitochondrial unfolded protein response (UPRmt). This occurs owing to movement of the transcription factor ATFS-1 from the mitochondrion to the nucleus, where it activates UPRmt genes, causing changes in cellular behaviour. Liu et al.1 report that metabolic products secreted from bacterial cells can induce the UPRmt. The authors find that the same response can be brought about by intracellular synthesis of metabolites such as ceramide or products of the mevalonate pathway, which is inhibited by statin drugs.

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