Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A is for immunity

If a pregnant mouse lacks vitamin A, her offspring are born with smaller lymph nodes and have impaired immune responses as adults — a finding that adds immune development to this vitamin's list of key functions. See Letter p.123

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Vitamin A regulates innate and adaptive immune responses.


  1. van de Pavert, S. A. et al. Nature 508, 123–127 (2014).

    Article  ADS  CAS  Google Scholar 

  2. Bang, B. G., Bang, F. B. & Foard, M. A. Am. J. Pathol. 68, 147–162 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Jurin, M. & Tannock, I. F. Immunology 23, 283–287 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Cantorna, M. T., Nashold, F. E. & Hayes, C. E. J. Immunol. 152, 1515–1522 (1994).

    CAS  PubMed  Google Scholar 

  5. Iwata, M. et al. Immunity 21, 527–538 (2004).

    Article  CAS  Google Scholar 

  6. Mucida, D. et al. Science 317, 256–260 (2007).

    Article  ADS  CAS  Google Scholar 

  7. DePaolo, R. W. et al. Nature 471, 220–224 (2011).

    Article  ADS  CAS  Google Scholar 

  8. Spits, H. & Di Santo, J. P. Nature Immunol. 12, 21–27 (2011).

    Article  CAS  Google Scholar 

  9. Spencer, S. P. et al. Science 343, 432–437 (2014).

    Article  ADS  CAS  Google Scholar 

  10. Mebius, R. E., Rennert, P. & Weissman, I. L. Immunity 7, 493–504 (1997).

    Article  CAS  Google Scholar 

  11. Eberl, G. et al. Nature Immunol. 5, 64–73 (2004).

    Article  CAS  Google Scholar 

  12. Ivanov, I. I. et al. Cell 126, 1121–1133 (2006).

    Article  CAS  Google Scholar 

  13. van de Pavert, S. A. et al. Nature Immunol. 10, 1193–1199 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gérard Eberl.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Eberl, G. A is for immunity. Nature 508, 47–48 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing