Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genetics

Closing the distance on obesity culprits

Subjects

Genetic variation in a non-protein-coding region of the gene FTO is implicated in obesity. A study finds evidence that, rather than affecting FTO itself, variations in this region influence expression of a distant gene, IRX3. See Letter p.371

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Long-range control of gene expression.

References

  1. Frayling, T. M. et al. Science 316, 889–894 (2007).

    Article  ADS  CAS  Google Scholar 

  2. Scuteri, A. et al. PLoS Genet. 3, e115 (2007).

    Article  Google Scholar 

  3. Dina, C. et al. Nature Genet. 39, 724–726 (2007).

    Article  CAS  Google Scholar 

  4. Fischer, J. et al. Nature 458, 894–898 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Church, C. et al. Nature Genet. 42, 1086–1092 (2010).

    Article  CAS  Google Scholar 

  6. Smemo, S. et al. Nature 507, 371–375 (2014).

    Article  ADS  CAS  Google Scholar 

  7. Ragvin, A. et al. Proc. Natl Acad. Sci. USA 107, 775–780 (2010).

    Article  ADS  CAS  Google Scholar 

  8. van de Werken, H. J. G. et al. Nature Methods 9, 969–972 (2012).

    Article  CAS  Google Scholar 

  9. Maurano, M. T. et al. Science 337, 1190–1195 (2012).

    Article  ADS  CAS  Google Scholar 

  10. Sanyal, A., Lajoie, B. R., Jain, G. & Dekker, J. Nature 489, 109–113 (2012).

    Article  ADS  CAS  Google Scholar 

  11. Jin, F. et al. Nature 503, 290–294 (2013).

    Article  ADS  CAS  Google Scholar 

  12. Lettice, L. A. et al. Hum. Mol. Genet. 12, 1725–1735 (2003).

    Article  CAS  Google Scholar 

  13. Visser, M., Kayser, M. & Palstra, R.-J. Genome Res. 22, 446–455 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to David U. Gorkin or Bing Ren.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorkin, D., Ren, B. Closing the distance on obesity culprits. Nature 507, 309–310 (2014). https://doi.org/10.1038/nature13212

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13212

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing