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Genetics

Closing the distance on obesity culprits

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Genetic variation in a non-protein-coding region of the gene FTO is implicated in obesity. A study finds evidence that, rather than affecting FTO itself, variations in this region influence expression of a distant gene, IRX3. See Letter p.371

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Figure 1: Long-range control of gene expression.

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Correspondence to David U. Gorkin or Bing Ren.

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Gorkin, D., Ren, B. Closing the distance on obesity culprits. Nature 507, 309–310 (2014). https://doi.org/10.1038/nature13212

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