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Bone biology

Vessels of rejuvenation

The identification of specialized endothelial-cell populations in the blood vessels of bones, and their signalling pathways, reveals how the vasculature contributes to bone formation. See Article p.323 & Letter p.376

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Figure 1: Type H endothelial cells couple angiogenesis to osteogenesis.


  1. Potente, M., Gerhardt, H. & Carmeliet, P. Cell 146, 873–887 (2011).

    Article  CAS  Google Scholar 

  2. Ding, B. S. et al. Nature 505, 97–102 (2014).

    Article  ADS  Google Scholar 

  3. Hu, J. et al. Science 343, 416–419 (2014).

    Article  ADS  CAS  Google Scholar 

  4. Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Nature 507, 323–328 (2014).

    Article  ADS  CAS  Google Scholar 

  5. Ramasamy, S. K., Kusumbe, A. P., Wang, L. & Adams, R. H. Nature 507, 376–380 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Pugh, C. W. & Ratcliffe, P. J. Nature Med. 9, 677–684 (2003).

    Article  CAS  Google Scholar 

  7. Thomas, J. L. et al. Cell Mol. Life Sci. 70, 1779–1792 (2013).

    Article  CAS  Google Scholar 

  8. Wong, B. W., Kuchnio, A., Bruning, U. & Carmeliet, P. Trends Biochem. Sci. 38, 3–11 (2013).

    Article  CAS  Google Scholar 

  9. Wan, C. et al. Proc. Natl Acad. Sci. USA 105, 686–691 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Whitaker, M., Guo, J., Kehoe, T. & Benson, G. N. Engl. J. Med. 366, 2048–2051 (2012).

    Article  CAS  Google Scholar 

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Correspondence to Ferdinand le Noble.

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le Noble, F., le Noble, J. Vessels of rejuvenation. Nature 507, 313–314 (2014).

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