Corrigendum | Published:

Corrigendum: Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

Nature volume 508, page 420 (17 April 2014) | Download Citation

Nature 499, 491–495 (2013); doi:10.1038/nature12396

After publication of this Letter, we became aware that we had not reported the details of construction and validation of our floxed conditional deletion Ptpn11 allele. These details are presented in the Supplementary Methods and Supplementary Fig. 1 of this Corrigendum. We also stated in our manuscript that PTPN11 is not mutated in human hepatocellular carcinoma, but it has been brought to our attention that a low frequency of copy number abnormalities involving the PTPN11 locus in this disorder has been reported1. However, comparable numbers of amplifications and deletions were observed, making it difficult to conclude from the data in ref. 1 that PTPN11 acts as a tumour suppressor gene in hepatocellular carcinoma.


  1. 1.

    et al. Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. Am. J. Pathol. 180, 1495–1508 (2012)

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    Supplementary Information

    This file contains Supplementary methods, Supplementary References and Supplementary Figure 1.

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