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Cell biology

Stressful genetics in Crohn's disease

A common variant of the autophagy protein ATG16L1 is a risk factor for Crohn's disease. But the genetic alteration is revealed only when the protein is cleaved by the enzyme caspase 3 during cellular stress. See Article p.456

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Figure 1: Fate determination by caspase 3.

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Correspondence to Arthur Kaser or Richard S. Blumberg.

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Kaser, A., Blumberg, R. Stressful genetics in Crohn's disease. Nature 506, 441–442 (2014). https://doi.org/10.1038/nature13060

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