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Genetic rejuvenation of old muscle

In advanced age, the stem cells responsible for muscle regeneration switch from reversible quiescence to irreversible senescence. Targeting a driver of senescence revives muscle stem cells and restores regeneration. See Article p.316

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Figure 1: Old age disrupts muscle regeneration.


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Correspondence to Juan Carlos Izpisua Belmonte.

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Li, M., Belmonte, J. Genetic rejuvenation of old muscle. Nature 506, 304–305 (2014).

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