Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer

Interference identifies immune modulators

Nature volume 506, pages 39–40 (2014)Cite this article

Subjects

A broad in vivo screen of the effects of specific gene inhibition on the antitumour activity of immune cells in mice bearing melanomas has revealed potential targets for cancer therapy. See Article p.52

Therapies designed to boost the immune system's response to tumours hold great promise for overcoming drug resistance in cancer. Advanced solid tumours inevitably develop resistance against currently available cytotoxic or molecularly targeted therapies, but durable responses have been observed following some immunotherapeutic treatments, leading to speculation that a cure for some patients could be possible. On page 52 of this issue, Zhou et al.1 use RNA-interference technology to identify genes that can be targeted to enhance the robustness and proliferation of immune cells called CD8+ T cells in mice bearing melanomas.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Figure 1: Screening for T-cell modulators.

References

  1. Zhou, P. et al. Nature 506, 52–57 (2014).

    CAS  Article  ADS  Google Scholar 

  2. Hodi, F. S. et al. N. Engl. J. Med. 363, 711–723 (2010).

    CAS  Article  Google Scholar 

  3. Topalian, S. L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).

    CAS  Article  Google Scholar 

  4. Robert, C. et al. N. Engl. J. Med. 364, 2517–2526 (2011).

    CAS  Article  Google Scholar 

  5. Zender, L. et al. Cell 135, 852–864 (2008).

    CAS  Article  Google Scholar 

  6. Berns, K. et al. Cancer Cell 12, 395–402 (2007).

    CAS  Article  Google Scholar 

  7. Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B. & Hemann, M. T. Nature Genet. 41, 1133–1137 (2009).

    CAS  Article  Google Scholar 

  8. Bric, A. et al. Cancer Cell 16, 324–335 (2009).

    CAS  Article  Google Scholar 

  9. Guo, L. et al. Proc. Natl Acad. Sci. USA 110, E1849–E1856 (2013).

    CAS  Article  Google Scholar 

  10. Wuestefeld, T. et al. Cell 153, 389–401 (2013).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lars Zender is at the University of Tübingen, 72076 Tübingen, Germany, and at the German Center for Translational Cancer Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.,

    Lars Zender

Authors
  1. Lars Zender
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lars Zender.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zender, L. Interference identifies immune modulators. Nature 506, 39–40 (2014). https://doi.org/10.1038/nature13050

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13050

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing