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A suppression switch

The status of the protein p53 determines whether inhibiting the cellular autophagy pathway promotes or inhibits pancreatic cancer in mice. This finding serves as a cautionary tale for clinical trials of autophagy inhibitors. See Letter p.296

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Figure 1: Autophagy, p53 and cancer progression.


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Correspondence to Jayanta Debnath.

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Starobinets, H., Debnath, J. A suppression switch. Nature 504, 225–226 (2013).

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