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Stem cells

Dual response to Ras mutation

Proliferation-driving mutations in haematopoietic stem cells often result in the loss of stem-cell properties. But at least one common oncogenic mutation seems to enhance both proliferation and stem-cell self-renewal. See Letter p.143

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Figure 1: Bimodal behaviour.

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Correspondence to Scott A. Armstrong.

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Chu, S., Armstrong, S. Dual response to Ras mutation. Nature 504, 91–92 (2013). https://doi.org/10.1038/nature12840

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