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Biochemistry

Metal ghosts in the splicing machine

Chemical analysis of the spliceosome's active site reveals that it is the RNA components of this enzyme complex that coordinate the catalytic metal ions responsible for production of a spliced messenger RNA. See Article p.229

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Figure 1: Active sites of group II introns and the spliceosome.

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Correspondence to Scott A. Strobel.

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Strobel, S. Metal ghosts in the splicing machine. Nature 503, 201–202 (2013). https://doi.org/10.1038/nature12705

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