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Killing from the inside

Lysosomes are the main degradative compartment in cells, but they are also involved in cell-death pathways. Studies using existing drugs show that lysosomes are excellent pharmacological targets for selectively destroying cancer cells.

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Figure 1: Lysosomes as a therapeutic cancer target.


  1. *This News & Views article was published online on 2 October 2013.


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Correspondence to Paul Saftig.

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Saftig, P., Sandhoff, K. Killing from the inside. Nature 502, 312–313 (2013).

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