Letter | Published:

The origin of conodonts and of vertebrate mineralized skeletons

Nature volume 502, pages 546549 (24 October 2013) | Download Citation

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Abstract

Conodonts are an extinct group of jawless vertebrates whose tooth-like elements are the earliest instance of a mineralized skeleton in the vertebrate lineage1,2, inspiring the ‘inside-out’ hypothesis that teeth evolved independently of the vertebrate dermal skeleton and before the origin of jaws3,4,5,6. However, these propositions have been based on evidence from derived euconodonts. Here we test hypotheses of a paraconodont ancestry of euconodonts7,8,9,10,11 using synchrotron radiation X-ray tomographic microscopy to characterize and compare the microstructure of morphologically similar euconodont and paraconodont elements. Paraconodonts exhibit a range of grades of structural differentiation, including tissues and a pattern of growth common to euconodont basal bodies. The different grades of structural differentiation exhibited by paraconodonts demonstrate the stepwise acquisition of euconodont characters, resolving debate over the relationship between these two groups. By implication, the putative homology of euconodont crown tissue and vertebrate enamel must be rejected as these tissues have evolved independently and convergently. Thus, the precise ontogenetic, structural and topological similarities between conodont elements and vertebrate odontodes appear to be a remarkable instance of convergence. The last common ancestor of conodonts and jawed vertebrates probably lacked mineralized skeletal tissues. The hypothesis that teeth evolved before jaws and the inside-out hypothesis of dental evolution must be rejected; teeth seem to have evolved through the extension of odontogenic competence from the external dermis to internal epithelium soon after the origin of jaws.

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Acknowledgements

The SRXTM experiments were performed on the TOMCAT beamline at the Swiss Light Source, Paul Scherrer Institut (Villigen, Switzerland), funded through a project awarded to P.C.J.D. and S. Bengtson (Stockholm). NERC grant NE/G016623/1 to P.C.J.D., a studentship to DJEM funded by NERC and the Paul Scherrer Institut, and NSFC Project 41372015 to X.-P.D. Thanks to R. Stamm (USGS) for reviewing a draft of this manuscript; and thanks to J. E. Cunningham, D. O. Jones and M. Rücklin for assistance at the beamline. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.

Author information

Affiliations

  1. School of Earth Sciences, University of Bristol, Wills Memorial Building, Queen’s Road, Bristol BS8 1RJ, UK

    • Duncan J. E. Murdock
    •  & Philip C. J. Donoghue
  2. School of Earth and Space Science, Peking University, Beijing 100871, China

    • Xi-Ping Dong
  3. State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China

    • Xi-Ping Dong
  4. US Geological Survey, MS 926A, National Center, Reston, Virginia 20192, USA

    • John E. Repetski
  5. Swiss Light Source, Paul Scherrer Institut, Villigen 5232, Switzerland

    • Federica Marone
    •  & Marco Stampanoni
  6. Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Rämistrasse, Zürich 8006, Switzerland

    • Marco Stampanoni

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Contributions

D.J.E.M. and P.C.J.D. conceived and designed the research; D.J.E.M., F.M. and M.S. collected the SRXTM data; J.E.R. and X.-P.D. provided material and taxonomic information; D.J.E.M. analysed the data, prepared the figures and wrote the paper with substantive edits from P.C.J.D. and minor edits from the remaining authors.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Philip C. J. Donoghue.

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https://doi.org/10.1038/nature12645

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