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Stem cells

Down's syndrome link to ageing

Triplication of the enzyme USP16 in models of Down's syndrome creates defects in the stem cells resident in adult tissues. This finding provides insight into stem-cell homeostasis during ageing. See Article p.380

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Figure 1: An altered threshold for stress.


  1. *This article and the paper under discussion1 were published online on 11 September 2013.


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Correspondence to Norman E. Sharpless.

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Souroullas, G., Sharpless, N. Down's syndrome link to ageing. Nature 501, 325–326 (2013).

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