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Stem cells

Down's syndrome link to ageing

Nature volume 501, pages 325–326 (2013)Cite this article

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Triplication of the enzyme USP16 in models of Down's syndrome creates defects in the stem cells resident in adult tissues. This finding provides insight into stem-cell homeostasis during ageing. See Article p.380

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Figure 1: An altered threshold for stress.

Notes

  1. *This article and the paper under discussion1 were published online on 11 September 2013.

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Authors and Affiliations

  1. George P. Souroullas and Norman E. Sharpless are in the Departments of Medicine and Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA.,

    George P. Souroullas & Norman E. Sharpless

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  1. George P. Souroullas
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  2. Norman E. Sharpless
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Correspondence to Norman E. Sharpless.

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Souroullas, G., Sharpless, N. Down's syndrome link to ageing. Nature 501, 325–326 (2013). https://doi.org/10.1038/nature12558

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