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A long genetic explanation

Topoisomerase enzymes facilitate gene transcription by resolving DNA tangles. Malfunction of these enzymes seems to compromise the expression of very long genes, potentially mediating neurodevelopmental disorders. See Article p.58

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Figure 1: Topoisomerase inhibitors and transcription.


  1. *This article and the paper under discussion1 were published online on 28 August 2013.


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Correspondence to Marisa S. Bartolomei.

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Plasschaert, R., Bartolomei, M. A long genetic explanation. Nature 501, 36–37 (2013).

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