Topoisomerase enzymes facilitate gene transcription by resolving DNA tangles. Malfunction of these enzymes seems to compromise the expression of very long genes, potentially mediating neurodevelopmental disorders. See Article p.58
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
*This article and the paper under discussion1 were published online on 28 August 2013.
King, I. F. et al. Nature 501, 58–62 (2013).
Kishino, T., Lalande, M. & Wagstaff, J. Nature Genet. 15, 70–73 (1997).10.1038/ng0197-70
Huang, H.-S. et al. Nature 481, 185–189 (2011).
Neale, B. M. et al. Nature 485, 242–245 (2012).
Iossifov, I. et al. Neuron 74, 285–299 (2012).
Joshi, R. S., Piña, B. & Roca, J. Nucleic Acids Res. 40, 7907–7915 (2012).
Peter, B. J. et al. Genome Biol. 5, R87 (2004).
Kouzine, F., Sanford, S., Elisha-Feil, Z. & Levens, D. Nature Struct. Mol. Biol. 15, 146–154 (2008).
About this article
Cite this article
Plasschaert, R., Bartolomei, M. A long genetic explanation. Nature 501, 36–37 (2013). https://doi.org/10.1038/nature12553
This article is cited by
The Patient - Patient-Centered Outcomes Research (2019)
Wiener Medizinische Wochenschrift (2017)