Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

B-cell development in the gut

Nature volume 501, pages 42–43 (2013)Cite this article

Subjects

B cells arise in the bone marrow and go on to produce antibodies that protect against microbial infection. Surprisingly, it seems that B-cell development also occurs in the gut, where it is stimulated by resident microbes. See Letter p.112

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Receptor editing.

Notes

  1. *This article and the paper under discussion4 were published online on 21 August 2013.

References

  1. Ley, R. E., Peterson, D. A. & Gordon, J. I. Cell 124, 837–848 (2006).

    Article  CAS  Google Scholar 

  2. Round, J. L. & Mazmanian, S. K. Nature Rev. Immunol. 9, 313–323 (2009).

    Article  CAS  Google Scholar 

  3. Ivanov, I. I. et al. Cell 139, 485–498 (2009).

    Article  CAS  Google Scholar 

  4. Wesemann, D. R. et al. Nature 501, 112–115 (2013).

    Article  ADS  CAS  Google Scholar 

  5. Jung, D. & Alt, F. W. Cell 116, 299–311 (2004).

    Article  CAS  Google Scholar 

  6. Nemazee, D. Nature Rev. Immunol. 6, 728–740 (2006).

    Article  CAS  Google Scholar 

  7. Kuo, T. C. & Schlissel, M. S. Curr. Opin. Immunol. 21, 173–178 (2009).

    Article  CAS  Google Scholar 

  8. Constantinescu, A. & Schlissel, M. S. J. Exp. Med. 185, 609–620 (1997).

    Article  CAS  Google Scholar 

  9. Wolf, J. L. & Bye, W. A. Annu. Rev. Med. 35, 95–112 (1984).

    Article  CAS  Google Scholar 

  10. Lanning, D., Zhu, X., Zhai, S.-K. & Knight, K. L. Immunol. Rev. 175, 214–228 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mark Schlissel is in the Departments of Molecular Biology, Cell Biology, and Biochemistry and Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.,

    Mark Schlissel

Authors
  1. Mark Schlissel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark Schlissel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schlissel, M. B-cell development in the gut. Nature 501, 42–43 (2013). https://doi.org/10.1038/nature12551

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12551

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing