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Gene regulation

Long RNAs wire up cancer growth

Nature volume 500, pages 536–537 (2013)Cite this article

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The discovery of long non-coding RNAs that control the liaisons between a transcription factor with a key role in prostate cancer and its target genes sheds light on how RNAs dictate information flow in the cell nucleus. See Letter p.598

The human genome generates more than 10,000 long non-coding RNA (lncRNA) molecules, yet the functions of only several dozen of these transcripts are known. On page 598 of this issue, Yang et al.1 describe two lncRNAs that bind to, and govern the function of, the androgen receptor — a transcription factor that activates the expression of thousands of genes in response to the hormone androgenFootnote 1. The authors find that inhibition of these two lncRNAs can block the growth of prostate-cancer cells that are resistant to hormone therapy owing to a mutation in the androgen receptor.

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Figure 1: Long non-coding RNAs and prostate-cancer growth.

Notes

  1. *This article and the paper under discussion1 were published online on 14 August 2013.

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Authors and Affiliations

  1. Adam M. Schmitt and Howard Y. Chang are at the Howard Hughes Medical Institute and the Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.,

    Adam M. Schmitt & Howard Y. Chang

  2. A.M.S. is also in the Department of Radiation Oncology, Stanford University School of Medicine.,

    Adam M. Schmitt

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  1. Adam M. Schmitt
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  2. Howard Y. Chang
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Correspondence to Howard Y. Chang.

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Schmitt, A., Chang, H. Long RNAs wire up cancer growth. Nature 500, 536–537 (2013). https://doi.org/10.1038/nature12548

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